HESI Pharmacology Exam Preparation – 2025 Nursing Review with Practice Tests, Expert Answer Explanations, and NCLEX-Aligned Strategies

• Focused prep for HESI Pharmacology Exam 2025
• Practice tests with expert answer explanations
• NCLEX-aligned strategies for nursing students
• Strengthens pharmacology knowledge for RN candidates
• Boosts confidence for exam success

Preview

1.) Cycloserine (Seromycin) is added to the medication regimen for a client with
tuberculosis. Which of the following would the nurse include in the client-teaching plan
regarding this medication?
1. To take the medication before meals
2. To return to the clinic weekly for serum drug-level testing
3. It is not necessary to call the health care provider (HCP) if a skin rash occurs.
4. It is not necessary to restrict alcohol intake with this medication. – – correct ans- -2. To
return to the clinic weekly for serum drug-level testing Rationale:
Cycloserine (Seromycin) is an antitubercular medication that requires weekly serum drug
level determinations to monitor for the potential of neurotoxicity. Serum drug levels lower
than 30 mcg/mL reduce the incidence of neurotoxicity. The medication must be taken after
meals to prevent gastrointestinal irritation. The client must be instructed to notify the HCP if
a skin rash or signs of central nervous system toxicity are noted. Alcohol must be avoided
because it increases the risk of seizure activity.
2.) A client with tuberculosis is being started on antituberculosis therapy with isoniazid
(INH). Before giving the client the first dose, a nurse ensures that which of the following
baseline studies has been completed?
1. Electrolyte levels
2. Coagulation times
3. Liver enzyme levels
4. Serum creatinine level – – correct ans- -3. Liver enzyme levels Rationale:
INH therapy can cause an elevation of hepatic enzyme levels and hepatitis. Therefore, liver
enzyme levels are monitored when therapy is initiated and during the first 3 months of
therapy. They may be monitored longer in the client who is greater than age 50 or abuses
alcohol.
3.) Rifabutin (Mycobutin) is prescribed for a client with active Mycobacterium avium
complex (MAC) disease and tuberculosis. The nurse monitors for which side effects of the
medication? Select all that apply.
1. Signs of hepatitis
2. Flu-like syndrome
3. Low neutrophil count
4. Vitamin B6 deficiency
5. Ocular pain or blurred vision
6. Tingling and numbness of the fingers – – correct ans- -1. Signs of hepatitis
2. Flu-like syndrome
3. Low neutrophil count 5. Ocular pain or blurred vision
Rationale:
Rifabutin (Mycobutin) may be prescribed for a client with active MAC disease and
tuberculosis. It inhibits mycobacterial DNA-dependent RNA polymerase and suppresses
protein synthesis. Side effects include rash, gastrointestinal disturbances, neutropenia (low
neutrophil count), red-orange body secretions, uveitis (blurred vision and eye pain),
myositis, arthralgia, hepatitis, chest pain with dyspnea, and flu-like syndrome. Vitamin B6
deficiency and numbness and tingling in the extremities are associated with the use of
isoniazid (INH). Ethambutol (Myambutol) also causes peripheral neuritis.